Differin 0.1% Cream/Gel

33 reviews
from £29.95
Differin 0.1% Cream/Gel
  • Includes free private prescription

  • Free delivery over £40
  • 100% UK-based pharmacy
  • Free advice and support
  • We're rated 4.9 out of 5

Differin - Adapalene Acne Treatment

Are you looking to buy Differin gel - one of the best, and most popular, breakout-busting topical acne solutions? Start an online consultation and get a prescription for Differin cream & gel from The Independent Pharmacy today, and it will be delivered straight to your door as quickly as the next working day.

The active ingredient of Differin is adapalene, a form of vitamin A, which reduces the growth of keratin skin cells that would normally act to block pores in acne vulgaris.

Additionally, adapalene increases the turnover of surface skin cells, aiding the natural exfoliation of the skin. These dual actions help to clear acne and leave skin looking clear and oil-free.

  • Suitable for age:18 Years +
  • Maximums per order:
  • Consultation required?Yes

Differin 0.1% Cream/Gel Summary

Type of medicine
Works by
Active ingredient
Effective within
Pack size
Use with alcohol

We stock 2 different variants of Differin 0.1% Cream/Gel

View all prices

Differin - Important Information

  • What is Differin and what is it used for?

    Differin Cream and Gel are both prescription acne treatments that are applied directly to the skin, making Differin a great choice for people who cannot or who do not wish to take oral antibiotics. The active ingredient Adalpalene is effective at reducing inflammation helping to improve the appearance of blackheads, whiteheads, and pustules on the skin.

    Differin once daily Cream and Gel are manufactured by Galderma and are available in 45-gram tubes for mild to moderate acute acne. Most people will notice an improvement to their skin in just a few weeks, however, Differin must be used daily for a full 3 months. Differin can be combined with a topical or oral antibiotic for more severe acne.

    How Differin gel works

    The active ingredient in Differin, Adapalene, is a form of vitamin A and it works to reduce the growth of keratin surface skin cells that can block pores. Sebum is a natural, oily substance produced by glands just under the surface of the skin called sebaceous glands, needed to keep the skin smooth and supple. Sufferers of acne often produce too much sebum, which can mix with the dead keratin skin cells and cause the pores to become blocked.

    Blocked pores can then lead to the formation of spots, blackheads (comedones) and whiteheads. Applying Differin 0.1% Cream to the affected areas will help reduce the amount of keratin skin cells and unblock the pores and sebaceous glands, allowing the sebum to escape. This will result in a reduction of inflammation, whiteheads, comedones and spots.

    Differin 0.1% cream/gel is also beneficial as it increases the natural turnover of the skin cells. This aids the natural exfoliation of the skin’s outer layers. This action will help keep pores unblocked, thus reducing the formation of spots and blackheads.

    Alternatives to Differin

    Acne is a very common skin complaint that can affect individual people differently, meaning that some people will find certain treatments more effective than others. It is recommended that if you do suffer from acne you start off by trying over-the-counter treatments. These treatments include:

    If you have tried over-the-counter treatments and these have not been effective, you should speak to your GP about further prescription-only options. For details on all our acne treatments please take a look at our Advice for Acne page.

    If you'd like to learn more about different acne treatments, read our Adapalene Vs Tretinoin comparison page.


  • How to use Differin

    • Differin cream/gel should be applied to the affected areas once daily in the evening, after washing with a mild cleanser.
    • Apply a small amount to cover the affected areas using clean fingertips and rub in lightly.
    • At the start of treatment with Differin, if it is used correctly it will produce effects similar to that of mild sunburn including mild itching, redness and warmth. This is normal and should subside.

    To get the best effects from Differin cream/gel it is important that it is for up to THREE months continuously depending on response. Improvement should be seen after a few weeks. This period is called the ‘Differin purge’.

    You may use cosmetics and moisturisers whilst you are using Differin cream however you should wait for it to be fully absorbed into the skin before applying anything else. Differin has a drying effect on the skin so it is important to try to ensure that any toiletries containing alcohol or other skin-drying ingredients are not used.

  • Differin ingredients

    Differin contains the active ingredient: adapalene 0.1%.

    Differin Cream also contains: Carbomer 934P, Macrogol-20 methyl glucose sesquistearate, glycerol (E422), natural squalene, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), disodium edetate, methyl glucose sesquistearate, phenoxyethanol, cyclomethicone, sodium hydroxide & purified water.

  • Differin side effects

    Like all topical applications, there is the potential that you may be allergic to Differin. We recommend you do a spot test before commencing treatment.

    If you do experience side effects from Differin cream/gel, they can include:

    • a burning, stinging or tingling feeling
    • dry skin
    • itching or redness
    • a rash

    See our Differin side effects page for more information and make sure to read the Patient Information Leaflet enclosed with your medicines for a full list of side effects, before applying.

    It is usually well-tolerated and gets positive ratings from patients who review Differin.

    If you experience any adverse effects from taking your prescribed medicine it is important to let us know immediately. Please log in to your online account and message one of our healthcare professionals or alternatively call us on 0333 2200519. In a medical emergency, you should contact the emergency services or go straight to your local Accident & Emergency.

  • Differin Warnings

    • Do not use this medicine on areas where you have cuts or scrapes or if you have a skin condition called eczema.
    • Avoid contact with the eyes, mouth or nostrils, and avoid other very sensitive areas of the body. If accidental contact does occur, immediately wash with warm water.
    • Avoid exposure to strong sunlight and artificial UV light. If you experience sensitivity or irritation when applying this medicine, stop using it and tell your doctor. You may be asked to use the gel less often or to stop using it for a short time. Talk to your doctor or pharmacist if you are not sure.

    Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines:

    • Other acne products (containing benzoyl peroxide, erythromycin or clindamycin) may be used with Differin but they must be applied in the morning and Differin at night.
    • Cosmetics may be used but they must not cause blackheads or dry the skin.

    Pregnancy and breastfeeding

    • Differin should not be used during pregnancy. If you fall pregnant while using Differin, the treatment must be discontinued and you should inform your doctor as soon as possible for a further follow-up.
Differin 0.1% Cream/Gel reviews

Differin 0.1% Cream/Gel FAQs

  • Yes, we understand that sometimes you want to get your acne treatment as soon as possible. If ordered before 4pm Monday to Friday, our doctors will review your consultation for Differin the same day. If it is approved your order is can be delivered as quickly as the next day.

  • Yes, as long as you are buying from a website that is a legally operating and regulated pharmacy it is perfectly safe to buy Differin online. The Independent Pharmacy is an NHS-licensed Online Pharmacy based in Bristol and has all the necessary regulation to be able to safely provide convenient access to genuine acne prescription treatments through our Online Pharmacy & Online Doctor.

  • There are many advantages to buying Differin online, some include:

    • It's quick & easy - there is no need to spend time at the doctor or pharmacy.
    • Fast delivery - We offer same day dispatch before 4pm and fast delivery to your address of choice with Royal Mail.
    • Great prices - we are able to offer very competitive prices and we guarantee to beat any other Online Doctor service.
    • Tons of information - we provide all the information you could need on Differin (adapalene/benzoyl peroxide) and other acne treatments, in easy to digest formats, at a time to suit you.

Still unsure about this treatment?

Ask our medical team for impartial information and advice about any treatment we provide or medical condition that we treat before you buy.

A small collection of medicines; A tube of orange ointment, a bottle of pills, and a tub of creamA doctor wearing glasses, with a stethoscope around his neck and an orange clipboard, welcoming a new customer with a wave

Related Treatments for Acne

  • Minocin


    Minocin MR capsules contain the antibiotic minocycline, for the treatment of mild to moderate acne. They help to kill the excess bacteria on the skin that contribute to the development of acne.

    • 100mg
    • 56 Capsules
    • Oral antibiotic, Branded treatment, Modified release
    22 reviews
  • Acnecide Moisturiser

    Acnecide Moisturiser

    • 50ml
    • SPF30, 24-hour hydration, Non-comedogenic
    1 review
    Acnecide Moisturiser

We stock 22 other treatments for Acne

View more treatments

How to order treatment from our online pharmacy

Find the ideal treatment
Get a free consultation
Enjoy our speedy delivery

Need something else?

We stock 857 treatments for 86 conditions

Or browse all treatments or conditions

Medical professionals standing unified looking for solutions to fix your health problem